Delay and Time Essay

Time never returns and its wise, judicious, useful utilization brings rich dividends to a person. For example, careful utilization of time on studies in young age rewards anyone with a good post afterwards and ensures a plentiful, Prosperous livelihood for the rest of life. Likewise, careful use time in youth helps a man make a prestigious place for himself in society. It earns him name, fame as well as Prosperity. But the tragedy is that many of us have absolutely no idea of the value of time in life. We perform our jobs in a haphazard way, miss appointments with ease and arrive late for any appointment, however important it may be. It is too hate for us to learn, much to our grief that time and tide wait for no man. Due respect for time rewards us with wealth as well as success. When a work is delayed, the time which could have been profitably used is wasted. Time lost is lost forever. There is no dearth of people in this world who complain that they have never had any luck and so have remained poor. But the reality, however, is that many cases of poverty are on account of the wasted opportunities and deferred tasks. Don’t forget that quite often we have to pay a very heavy price for delaying things. The person who prolongs taking insurance of his house usually regrets his folly, when the house is gutted by a sudden fire. Delay in the treatment of a disease may lead to its worsening and may, finally, even result in death. The student, who goes on postponing studies, never gets time to prepare for the examination and does very badly at the end. He remains under great mental strain and may even get confused in the examination hall at the time of writing his answers. A timely action in any direction, whatsoever, is a guarantee for success and perfection. This is why the wise often say ‘A stitch in time saves nine.’ There are a number of other proverbs conveying almost the same meaning. Thus we say : â€Å"Make hay while the sun shines; strike while the iron is hot; time and tide wait for none ; and â€Å"never put off till tomorrow, what you can do today.† But at the same time, we also have a few proverbs which contradict these proverbs. We say: â€Å"Haste makes waste; more haste, less speed; look before you leap† and â€Å"slow and steady wins the race.† But all these contradictory pieces of advice say only to be judicious and thoughtful. None of them asks you to waste an opportunity. In our limited period of short life, we have lots of things to do and hence the urgent need of managing our time properly and make the best use of each and every moment at our disposal. We shall be saved from regret, stress, tension and humiliation and will be able to make all-round progress, only if we understand properly how dangerous delay is and how important and precious time is!

Light Bulb

An essay on light bulb While many learned professors have abandoned hope of ever discovering the truth behind light bulb, I for one feel that it is still a worthy cause for examination. In depth analysis of light bulb can be an enriching experience. Cited by many as the single most important influence on post modern micro eco compartmentalism, it is yet to receive proper recognition for laying the foundations of democracy. Often it is seen as both a help and a hinderence to those most reliant on technology, trapped by their infamous history.With the primary aim of demonstrating my considerable intellect I will now demonstrate the complexity of the many faceted issue that is light bulb. Social Factors There is cultural and institutional interdependence between members of any community. When Sir Bernard Chivilary said ‘hounds will feast on society' [1] he borrowed much from light bulb. While the western world use a knife and fork, the Chinese use chopsticks. Of course light bulb irons out misconceptions from our consciousness. Status, Security, Fame – light bulb, all revolve around this ‘golden fleece'.To put it simply, people like light bulb. Economic Factors The preceding section may have shed some light on society but to really understand man you must know how he spends his money. We shall examine the Simple-Many-Pies model, a lovely model. Market Value Of Gold light bulb Clearly the graphs demonstrates a strong correlation. Why is this? Of course the market value of gold, ultimately decided by politicians, will always be heavily influenced by light bulb due to its consistently high profile in the portfolio of investors. Many analysts fear a subsequent depression.Political Factors Politics, we all agree, is a fact of life. Contrasting the numerous political activists campaigning for the interests of light bulb can be like looking at light bulb now, and its equivalent in the 1800s. In the words of jazz singer Demetrius Rock ‘Man's great est enemy is complacency with regards to personal and political hygiene. ‘ [2] This quotation leads me to suspect that he was not unaccustomed to light bulb. It speaks volumes. Perhaps the word which sums up the importance of light bulb to politics is ‘participation'.Since the Renaissance light bulb has become more and more prevalent. May it continue. Conclusion We can say with certainty light bulb plays a large part in the lives of all. It replenishes the self, ‘literally' plants seeds for harvest,, though light bulb brings with it obvious difficulties, it is truly light bulb. I will leave the last word to the famous Clint Jackson: ‘I would say without a shadow of a doubt: light bulb ROCKS!!! [3] [1] Sir Bernard Chivilary – Interestingly†¦ – 1904 Badger Books [2] Rock – Roll It Up – 1977 – F. Lower Publishing [3] Sham Magazine – Issue 124 – Monkey Books

PRAN †the Largest Agro Food Processor in Bangladesh Essay

Introduction Agricultural Marketing Company Limited (AMCL) was set up at first in 1981 and then 1985 for farming and marketing of agricultural products for local and export market. Subsequently a modern fruit processing plant with bottling and earning facilities was added in 1993 to produce fruit juice, squash, sherbet, jam, jelly etc. the company processing unit started commercially production in July 1993 and launched its products in the market under the brand name â€Å"PRAN†. PRAN stands for Programme for Rural Advancement Nationally. The brand Pran has established itself in every category of food and beverage industry and can boost a product range from Juices, Carbonated Drinks, Confectionery, Snacks, and Spices to even Dairy products. Pran Group was born keeping in view the corporate mission of the group. Today Pran is the largest processors of fruits & vegetables in Bangladesh. Pran is the pioneer in Bangladesh to be involved in contract farming. They encourage contract farmers and help them grow quality crops with increased yields and to obtain fair prices. They procure raw material directly from the farmers and processes through the machineries at their several factories into hygienically packed food and drinks products. The Group comprises of 10 companies. The head offices are located at Dhaka with production facilities around the country. Their management is modern adapted to the environment & culture and Pran’s largest asset is their competent team of hands-on-mangers & dedicated employees. Pran is listed with the Dhaka and Chitttgong stock exchanges in 1996. Pran agriculture marketing company limited has controlled the nine individual Business Units on their umbrella. Agro Industrial Park Bangladesh’s first-ever agro-industrial zone, Pran Agro Industrial Park, was inaugurated in Natore. The park is comprised of automatic rice mill, spice, peanut, honey, tomato, pickle, jam and jelly processing units, fruit pulping units, pulses mill, puffed rice mill, cattle feed mill, plastic molding and milk collection units to produce wide range of products, which is using for  export. Plant in India: Now Pran is going for FDI (Foreign Direct Investment) in India by building its first foreign factory in India, taking advantage of the country’s recent decision to lift its ban on Bangladeshi investment. The plant will be built in the north-eastern Indian state of Tripura. It will initially produce jelly and drinks and is expected to come into operation by 2009 with an annual turnover of around Tk100 crore. It will supply the markets of northeast India -Assam, Nagaland, Tripura, Meghalaya, Manipur, Mizoram and Arunachal Pradesh -known as ‘Seven Sisters’, said a senior official of Pran Exports Ltd. The plant will initially produce jelly and drinks, which have already won popularity in those areas, said Paramuddin Hossain, senior manager of Export of Pran Group. Related and Supporting Industries Pran Food Limited produce different types of food products which require many other related and supporting products in their different stages of production and distribution. I.Mango and Other Fruits Industry: Pran’s mango juice is their most selling item and most of their earnings are earned by selling mango juice. So they need a large amount of mango as a raw material in mango juice production. They also need mango in producing Jam, Pickles and Mango Bar. Besides Mango they also need many other fruits like Orange, Pineapple, Apple, Litchi, Lemon and many other fruits to produce Juice, Jam, Fruit Bar and Pickles. At present they supply mango and other fruits from their own garden as well as import from other countries like India and Bhutan. But the importing amount is more than the amount of supply from their own garden. II.Sugar Industry: Sugar is an inevitable raw material for production process in Pran Food  Limited. They need sugar in juice production to candy production. They use our home countries sugar because they do not import sugar for high tariff rate. So sugar industry is a related and supporting industry for Pran Food Limited. There are many local sugar industries that depend on Pran. III.Dairy Firm: Pran has the country’s largest milk producing centre. Pran’s own dairy firm supplies milk to produce Ghee, Milk candy, Mango Milk, Chocolate Milk, and in many other production process. If supply from their own dairy firm can not satisfy the need of raw materials in future other dairy firms can give them the supply. IV.Wheat Industry: Pran needs a bulk amount of wheat to produce snacks, like Crackers & Chips, Bakery Items, Biscuit, Chanachur, Dal etc. They import wheat from other countries for their production process. V.Packaging Industry: To distribute all products Pran needs quality and colorful packaging. At present they are importing all packaging materials excluded the glass bottle from China and Korea. And they use local glass bottle to distribute juice and pickles. Organizational Structure of Pran The Pran agriculture marketing company limited constructed their organizational structure in standard way which could efficient for their production and job. The structure is given below: Marketing Strategy of Pran To achieve its marketing objectives Pran uses the customer centered orientation program to gain large bulk of customers. First  of all they set Segmentation Targeting Positioning (STP) for their products. I.Market Segmentation: Pran segment their market to divide the market into distinct groups of buyers who have distinct needs, characteristics, or behavior and who require separate products or marketing mixes. For example: they segment their mango juice to think about the people of different age and who have different taste. Like Pran Mango Juice-Classic for generalized group, Pran Mango Juice-Premium for the group who want thick mango juice, Pran Joy Juice for the young generation and Pran Junior Juice for the children. II.Target Market: Pran target the middle class people who wants verified taste of foods. As consumer percentage is high in this group they think that this target market is highly profitable for them. So, they don’t go for high priced product rather than they try to serve low price but competitive quality of product. That is why their main object is to serve quality product at a lower price and they do a lot of promotional activities for being the best in the competitive market. III.Market Positioning: Pran positioning their products in their customers mind by offering special features and benefits. To occupy a clear, distinctive, and desirable place relative to competing products in the minds of their target market Pran tries to position their each and every product. For example; Pran tries to position the Mango Bar as a taste of the happiness of their childhood, in the mind of every consumer. IV.Marketing Mix of Pran: Pran has a set of controllable tactical marketing tools –product, price, place and promotion, which they blend to produce the response wanted by their target market. a)Product: Products act as customer solution for their demand. Pran has an extensive line of product which can easily satisfy the need for any food demand of the consumers. Consumers are getting all sorts of food products they need to consume from Pran. b)Price: Bangladesh has a huge shortage of fruit, vegetable, raw materials. So Pran make up this shortfall by importing from the neighboring and different countries like India, Bhutan, and China etc. But, for that, Pran needs a relaxed tariff structure to keep their products competitive. So, Pran follows competitive pricing strategy to compete in the market. But they also take care of the limitation of their customer. So they always try to keep the price low to compete in the market and to make their product’s price affordable for their consumers. c)Place: Pran has an extensive sales network throughout the country to reach their product to everyone. Their products are available even to the remote part of the country. Company appointed sales force to cover every part of the country. d)Promotion: Pran communicates with their consumers by various means of promotion. To maintain a good public relation they take intensive sales promotion. To promote Pran’s product to their customers, they are conducting some promotional activities. These include: Advertisement in print media such as news paper, magazine Advertisement in visual media with opinion leaders Free campaign Sponsoring in different cultural occasions V.Countrywide Sales and Distribution Network: Pran maintains the following distribution network Pran sales force comprises 137 Executives. Number of Sales Representatives is 1510. They are performing the responsibility of Selling to retailers all over Bangladesh through Distributors. At this moment company appointed total Distributors are 720. Mode of Transportation Pran use transportation in the following activities: I.To Import Raw Materials: To import the raw materials Pran use Freight on Board (FOB) and C&F both transportation system. On FOB the supplying company takes the responsibility to import raw materials up to Chittagong port and on C&F the supplying company imports the raw materials up to the factory. But Pran use the C&F system more than FOB system. II.To Export Processed Foods: Pran Food Limited uses the shipping system to export processed food to many other countries. To avoid the high transportation cost, they use shipping system instead of air. III.To Distribute In The Local Market: To avoid high freight Pran use their own distribution channel to distribute their products inside Bangladesh. They also take help of the local transportation agencies to distribute their products on payment. The names of some local transportation agencies that they use more frequently are given below: Haji Mostafa Transport Ananda Paribahan Shamim Transport Multi Star Transport Ltd. N. Mohammad Transport Packaging Packaging is the science, art and technology of enclosing or protecting products for distribution, storage, sale, and use. Packaging is very important part for the marketers because by looking at the packaging of product, consumers take the decision of buying a particular product. That is why Pran does colorful packaging which attracts customers a lot. Pran gives a lot of efforts in packaging. They are in a good position in doing  packaging compare to other companies in Bangladesh. Pran export their product in the international market, so comparing with the international market their process of packaging is not in a good pos ition at all. Pran is doing their best to compete with the international standard of packaging. For doing packaging they use foreign technologies to compete with the world market. They import package mostly from Thailand. Then they prefer China. They import different packing materials like- Aluminum Foil, Crown Cork, Flexible Packing material, Glass Bottle, Glass Jars, HDPE, Lug Cap (30, 53 & 63mm), PET, Shrink Labels, Shrink caps, Tin Can, U-Straw. Pran is doing packaging because of following reasons: i.Self-Service: Products should be packaging in such a process which is convenience for the consumers. Pran package their products in such a way that it is very convenience for the consumers to take products from one place to another. Pran do standardizing and grading their products according to different weight of their product. ii.Consumer Affluence: Pran always try to have bit more profit from customers. So Pran emphasize on appearance, dependability, and prestige of better package for having consumer affluence. iii.Company and Brand Image: Packages contribute to instant recognition of the company and brand. Pran packages their product in such a way that it’s become very easy for the customers to recognize their product. When Pran package their product, they emphasize a lot in few factors like- I.Physical Protection: Physical means the physical product. They emphasize whether products are secure after packaging or not. II.Barrier Protection: There are some problems that create product unhygienic, dust is one of them. To hygienic the product, Pran does their packaging very carefully. They concentrate on whether the packaging is protecting the products from different barrier or not. Pran use new types of technology for protecting these types of problem. III.Information Transmission: In packaging, Pran gives a lot of information about how to use products and what chemicals are their in the product. By doing these they do the work of information transmission which help a lot to the customers. IV.Security: There is possibility of damaging goods when products are going for shipment. Some time because of some defect in the packaging, products can not reach in there destination. For that reason companies loss their profit as well as their goodwill. That is why Pran emphasize a lot on security in packaging to prevent from these problems. Way of Packaging: The way that Pran packages their products can be shown in the following tables- Local Demand Condition Pran is the Bangladesh’s largest selling processed food company. The local demand for Pran’s product has increased day by day. The marketing officials explained that their current production volume even failed to satisfy the local demand condition in last year. The local demand condition of Pran’s product can easily determined by their sales volume. Here we examine Pran’s sales volume for last five years which shows that the local demand condition of their products has increased drastically. In 2004 the sales volume was worth of 50 crore taka which increased to 250 crore taka in 2008. That means the sales amount has increased by 40% in last five years. Foreign Demand Condition Like local demand condition Pran has a vast demand to the foreign market. They started to export from 2001 and from then on their foreign demand condition has just increasing and increasing. The foreign demand condition of Pran can be easily drawn by their exporting volume of last 8 years. We can see from the graph that at the beginning the only export worth 12 crore which increased by 16.67% in next year (2002). They had a slow increase in export up to 2005. Till then they had average increase of 17% each year in export. But they had a drastic change in export  from 2006 when their exporting volume rises by 55.55% from the previous year. They had exporting volume of 56 crore taka in 2006 and 80 crore in 2007. In last year they export worth 120 crore which break the all past record of increase in export. Market Access Issues Pran, Bangladesh’s largest agro process company produces and export different kinds of food products. Now they have access to many countries and have potential to export many other countries.

Rhetorical Communication Essay Example | Topics and Well Written Essays - 1000 words

Rhetorical Communication - Essay Example It is quite unusual to compare these forms of expression because they differ in purpose, appeal, argumentation, language usage, and eventually in literary devices presence. The most obvious difference concerns the aim of creation these two literary genres. Rhetoric always has a purpose, and its purpose is to persuade listeners in something. That is why despite the fact that Lincoln`s speech seems not to have obvious persuasion motive it is still aimed to influence the public in a certain way and provoke certain reaction. Lincoln is going to become a President for the second time and in his speech he needs to sum up his previous work. Nevertheless, he still needs to look in future that is why in his rhetoric he aims to combine his experience at president`s post with his expectations regarding future. The main topic of his speech is Civil War, and unfortunately the discussion of this topic is painful and unpleasant for the nation but the President needs to do it. In the very first paragraph Lincoln touches the topic of Civil War and outlines vague mood of the nation regarding this issue: â€Å"The progress of our arms, upon which all else chiefly depends, is as well known to the public as to myself, and it is, I trust, reasonably satisfactory and encouraging to all. With high hope for the future, no prediction in regard to it is ventured.† Further Lincoln briefly explains the situation, the reasons, and the negative consequences of the Civil War. Emily Dickenson as a poetess explores emotional side of the event and tries to demonstrate the War from her perspective of an ordinary citizen by examining the concepts of victory and defeat: Dickenson does not need to persuade someone in something, the aim of her poetry is self- discovery, deeper reflection, and expression of opinion on the topic. However, it is possible to suggest that the purpose of the poetry is elusive as the purpose of art in general as it mostly

The Interaction Of Byelikov And Kovalenko In The Man In A Case Essay - 61

The Interaction Of Byelikov And Kovalenko In The Man In A Case - Essay Example The conflict between these two people discloses the main idea of the story. The story has a very interesting structure – a story in the story, but at the same time, it doesn't prevent Chekhov from conveying the uniform assessment of human life perception, stating his ideas and outlooks. Plot composition of this story is simple and original. The prolog is the story of a gymnasium teacher Burkin telling to his friend, a veterinarian Ivan Ivanovich, a story about the teacher of Greek language Byelikov. We learn about the appearance and the way of life of the main character. The plot begins when a new teacher of history and geography Mikhail Savvich Kovalenko comes to the city. He comes with his younger sister Varinka whom Byelikov liked and considered marriage with her. The conflict of Byelikov and Kovalenko is the conflict of the people with absolutely different characters, different ideas, and moral principles, and it is the foundation of the story. Byelikov lived in panic, bei ng afraid of reality irritants. Byelikov praised the past, expressing disgust for the present and classic languages which he taught. He wore the same â€Å"an umbrella and galoshes† in which he was hiding from the real life. And everyone was afraid of this strange person. His thoughts were also hidden in a â€Å"case†. Nobody could know what he is thinking about and what he is going to do. Kovalenko, on the contrary, was open to people, he clearly expressed his opinion. A number of events make the culmination of the story: the desire of Byelikov and Varinka to get married, the drawn caricature of the main character, driving bicycles. All these actions excited Byelikov and provoked the conflict between him and Varinka’s brother. Belikov's death, which according to others serves as a solution to all the problems, is the outcome.

Morphine Essay Example | Topics and Well Written Essays - 3000 words

Morphine - Essay Example hat these other common drugs either match in action the effects of morphine when acted upon by the enzymes, or they increase the effectiveness of the enzymes resulting in a faster, or more concentrated catalytic effect (â€Å"Drugs.com†, 2011). In the case of lasix, which includes a psychotherapeutic and CNS-active agent the patient might experience hypotensive effects when the treatment is first administered or if either of the drugs dosage is increased. There is also a coadministration factor with vasodilators and alpha-blockers that can increase blood pressure and othostasis. This interaction is not consistent enough across all patients to come to a conclusion as to why this happens, but careful monitoring of any patient on this type of treatment method is advised (Hammack and Loprinzi, 1994). iii. Note the clinical consequences of each of the interactions (e.g. increases the plasma concentration of Drug B leading to an enhanced pharmacological effect and toxicity). In all of the drugs in the previous section (except lasix) the concern is that the drugs, when combined with morphine have an additive or synergetic effect on the toxicity and potency of both drugs thereby increasing effectiveness as well as possible side effects depending on how well individual patients metabolize the morphine. Factors that would need to be considered would include type of illness, health of the liver, enzyme production and any built up tolerance to either medication (American Pain Society, 1999). Lasix can interact with elements such as alpha blockers or vasodilators which would put more stress on the heart due to increased blood flow and/or respiratory system (American Pain Society, 1999). Section 3. Drug absorption For morphine: a. Determine and state the oral bioavailability... The study has shown that morphine is metabolized to M6G which is a potent analgesic thereby increasing the effectiveness of the drug in some situations. As a rule, the metabolism of morphine comes through uridine diphosphate glucuronosyl transferase (UGT) enzymes which are found in the liver. The enzymes form active analgesic metabolites and in some cases toxic metabolites as well. This would indicate that environmental factors that could inhibit or increase the effectiveness of morphine would include conjoint use of other drugs that reduce or inhibit the effect of liver enzymes; liver disease or a liver dysfunction and any drugs that can increase enzyme levels in the liver itself. According to the AHFS drug information the bioavailability is influenced by gastrointestinal absorption but the amount of bioavailability depends on the method that is used to administer it. In reality the bioavailability is almost 90% first pass hepatic extraction. This is supported by literature that sug gests that the clearance rate for morphine is longer in those individuals who have hepatic impairment. In most cases the morphine is metabolized in the liver and dispersed through urination. The rate of conventional oral preparations (immediate release) and the extended release oral versions are about the same but there is a difference in peak plasma concentrations which are longer and lower with the extended release oral preparation.

Change and Continuity in Contemporary Business Essay

Change and Continuity in Contemporary Business - Essay Example Denmark has flat organisational structure and informal work culture that facilitate in creating a comfortable working environment. The people of Denmark are straightforward in nature and wish for morality and honesty. The cost of living is quite high in Denmark due to its high salary structure. Furthermore, Danish managers generally have good understanding about satisfying the employees’ requirements. These are major internal aspects which influence on the business of Denmark. The external influences on businesses in Denmark include its strong regulatory system, good economic condition and stable political state. The tax structure in Denmark is comparatively high as the government of Denmark spends considerable money on social welfare activities. Globalisation has also influenced Denmark in numerous aspects. Globalisation is an unavoidable phenomenon which has both positive as well as negative influence on Denmark. On one side, globalisation has generated new prospects for con temporary business, but it also brings in challenges for organisations with respect to requirement of skilled workforce and capability for coping up with the competitors. However, Denmark is quite capable to manage the challenges of globalisation and take advantages of it. The influence of globalisation has been found on employment market, administrative policies, educational system, trade policies and business decision making. Denmark has effectively responded to globalisation’s impact. Due to globalisation, Denmark has reformed the monetary strategies. It has also reorganised the administration by reducing number of states and developing new regulations. Denmark’s entrepreneurship policies are also affected by globalisation with constant focus on entrepreneurial teaching and education. In order to maintain its position in the international economy, Denmark has close relationship with numerous international organisations. The immigration policies of Denmark have also changed considerably with increased focus on Danish language. The government has developed many new educational strategies in order to increase the competitiveness of people. Nevertheless, Denmark requires constant reformation of policies and strategies to get complete benefits from globalisation and tackle every challenge effectively. The government needs to ensure education for every Danish citizen. There is need for upgrading the educational curriculum. Furthermore, the government of Denmark must spend more on research and development functions to preserve the competitiveness of organisations. Strong regulations and effective policies are significant for Denmark to maintain its position in the world as a wealthy nation and retain the desirability of foreign companies. Table of Contents Executive Summary 2 Introduction 5 Literature Review 5 Critical Analysis 11 Conclusion and Recommendations 21 References 23 Bibliography 29 Introduction The report has been developed for analysing the contemporary business in Denmark. The aim of this report is to generate understanding about various internal as well as external factors of Denmark which can influence the business. The report includes position of Denmark in the world economy and influence of globalisation on its policies and decision making. Furthermore, the report also focuses on the effectiveness of Denmark in

Character analysis Essay Example | Topics and Well Written Essays - 1500 words

Character analysis - Essay Example â€Å"Never forget what you are. The rest of the world will not. Wear it like armor and it can never be used to hurt you† (Martin, 56). The dialogue is from George R.R Martin’s series, A ‘Song of Ice and Fire’, spoken by Tyrion Lannister, one of the most fascinating characters who carry a remarkable astuteness and intricate personality in the book. Apparently, his words indicate the great hopes and strong self-esteem that he possessed despite being a dwarf and believed that his physical disability does not imply his inability to deliver in life. Through his moving and treasured way of speaking, Tyrion shows outstanding ability of prudence and intuition. â€Å"As the most grandest creation† of the author Tyrion’s ambitions vitalizes on his unique perspective and open the new page of history on the great performance of a dwarf in media. Commendably, Tyrion sojourns on to attest that indeed the adversaries linked to his dwarfism can be overcome ( Ben, 01). Moreover, to fully comprehend the complexity and uniqueness of the characteristics of Tyrion, one must discern his childhood background. As a â€Å"high born dwarf† in an extremely dignified and arrogant family who had controlled their governance over seven kingdoms, Tyrion was not a son with interminable elegance and fondness. On the contrary, he has been depicted as a â€Å"midget† or â€Å"imp† who has been made an outcast by other characters in his family (Abraham et al., 116). Among different reasons behind people’s hatred towards Tyrion includes the death of his mother while she was giving birth to him. Tyrion Lannister does not share a strong bond with his only sister named Cersei Lannister. Nevertheless, his brother Jamie Lannister has a lot of compassion for Tyrion for which he has helped him throughout the novel. Additionally, the community of the Lannisters immensely ostracized Tyrion because he was expected to be

Guillermo Furniture Store Concepts Essay Example | Topics and Well Written Essays - 750 words

Guillermo Furniture Store Concepts - Essay Example The labor component in furniture manufacturing, in case of Guillermo, is substantial because all its products are hand-crafted and the company has no way to control its labor cost. On the contrary, it is on increase due to influx of other businesses for the favorable conditions in the region. Financial Concepts Involved Guillermo has to view the whole business scenario from a different perspective. If the company decides to be high-tech just like its competitor to replace its costly labor, then the company needs to estimate the risk-return trade-offs as making the company automated will require huge capital investment. In this process, Guillermo will need to apply numerous financial concepts to arrive at the conclusion whether it is worth investing huge capital to thwart the challenge posed by the competitor. First of all, the company needs to undertake a detailed budgeting exercise to evaluate the viability of high-tech model of manufacturing in its case. The company would need to e stimate the total fund requirement for going high-tech in this business. The company will have option of financing this capital expenditure either through equity or through mix of debt and equity. In the case of later, important thing will be to find appropriate debt-equity ratio for financing the project. Guillermo being a running and profitable company can certainly attract banks and other financial institutions to lend them for this project but leveraging should be within the prevailing norms as applicable for these kinds of businesses. High leveraging (high debt) creates higher business risk and that must be avoided as often occurs during economic slowdown. In a bid to ascertain financial viability of the investment, the company will need to estimate the break-even point in terms of volume (no. of pieces of each product variety) and value both. Break-even volumes will mean all revenue earnings meet all expenses of the company including fixed and variable ones. The break-even cal culations (Break-even analysis, 2012) will also force them to chalk its marketing and sales strategy – the distribution channels, number of retail shops and the geographical reach necessary to achieve those sales. The financial budget formation, capital required, capital structure deciding about equity-debt ratio, break-even volume analysis, cost of capital including weighted average cost of capital (Weighted Average Cost of Capital – WACC, 2012) present value of all expected future streams of revenue (Present value, 2012) until the useful life of machines, internal rate of return (Internal Rate of Return, 2012) will finally decide whether it is worth investing in the automation process so as to compete with the overseas firm effectively. Conclusion It is certain that Guillermo has gone through above mentioned detailed financial viability analysis to ascertain whether the company should go for this new business model or not. Having found the return on investment not lu crative, the company thought of outsourcing entire supply from a second competitor who has similar business model of manufacturing process

V&Cwk3 Essay Example | Topics and Well Written Essays - 1000 words

V&Cwk3 - Essay Example ent who comes for career counseling or any other counseling is a way to cause harm to the client which is a violation of A.4 (a), which says that counselors are to do no harm to their clients. Section B explains information about confidentiality and the most important section to me is B.1 (a) which talks about respecting client rights, taking into consideration multicultural and diversity issues. This section brings to mind that it is important to understand how different cultures see confidentiality, privacy views toward disclosure, and more (NCDA, p. 10). Since we live in a global world, it is important to be well rounded as a counselor. Section C speaks to professional responsibility, Capuzzi and Stauffer state that this section says that "professionals must perform at the highest level of their ability" (p. 97). I agree with this statement and section C.2 (a) is most important in this section because it says that career professionals must only work within the "boundaries of their competence" (NCDA, p. 15). This means as an example, that a career professional does not engage in mental health counseling because it is not within the scope of practice. I believe this is important because professionals must understand they cannot be everything to every client. They are governed by their "education, training, supervised experience, state and national professional credentials and appropriate professional experience" (NCDA, p. 15). The standards that I chose to compare with the NCDA standards re the American Counseling Association (ACA) standards. The first difference between these two that I see are the way they are set up for reading. The ACA standards have thee columns and each section is separated by a blue box so the reader knows which section they are in. The NCDA guidelines are easier to read because they are spaced out a little more. Both guidelines speak to the counseling relationship and they both say that counselors should avoid harm to clients. The ACA

A Tale of Two Cities by Charles Dickens Essay Example for Free

A Tale of Two Cities by Charles Dickens Essay Injustice is probably one of the oldest forms of hate known to man. Injustice can be found anywhere and in all forms of life. One of the most well known forms of injustice is slavery. Men and women of all ages and races suffer under slavery still to this day. Romania, for example, has been home to the unfortunate youth who are sold as prostitutes by their own parents! We all know that this is wrong, but society has driven us to not considering this as slavery, just cruelty. Obviously slavery is unjust, but some people to this date still do not know this because of the way they were brought up. However, what was once justified can, upon closer examination, be considered unjust. This was also the case during the revolution in France that began in 1789. Charles Dickens in A Tale of Two Cities described the many injustices that resulted from oppression in France. Injustice during the French Revolution affected everyone touched by it because the revolution claimed many victims on all sides. French peasants suffered, the aristocrats suffered, and innocent people suffered when the Revolution claims its victims. The unjust French government oppressed the poor peasants until they revolted in a bloody uprising. Everyone has a breaking point, and once it was reached, it was very hard to go back to a calm state. It was already bad that Marie Antoinette was using the tax money from the poor peasants to pay for her unnecessary dinner parties. Once Antoinette raised the taxes for that same purpose, it became unjust. This resulted in the beheading of Marie Antoinette. The wine was red wine, and had stained the ground of the narrow street in the suburb of Saint Antoine, in Paris, where it was spilled. It had stained many hands, too, and many faces, and many naked feet, and many wooden shoes. The hands of the man who sawed the wood, left red marks on the billets; and the forehead of the woman who nursed her baby, was stained with the stain of the old rag she wound about her head again. Those who had been greedy with the staves of the cask, had acquired a tigerish smear about the mouth; and one tall joker so besmirched, his head more out of a long squalid bag of a night-cap than in it, scrawled upon a wall with his finger dipped in muddy wine-leesblood (Dickens 37). The wine, which symbolizes blood, was smeared everywhere. This showed how desperate the French were to find some nourishment, even if it meant slurping wine off the city streets. It was amazing how a calm day in France changed into first come first serve madness. Also, the raiding of the Bastille showed how little the peasants could tolerate before retaliating. In this massacre, the peasants overpowered the guards to set the famous landmark on fire. Next, the aristocrats suffer from the united peasants uncontrollable anger and violence. One may wonder how the aristocrats and the peasants suffered at the same time? Before the Revolution, the aristocrats had all the money and happiness, but as the Revolution progressed, this happiness gradually converted into fear. Once the peasants realized that they made up the majority, they took advantage of this. The peasants anger drove them to imprisoning and killing every rich person in sight. Innocent people were killed just because they were rich. Aristocrats had no chance of survival because they were hated most. Anyone who worked for the government or even believed in what it stood for lived in a life of fear. The Marquis from A Tale of Two cities was too ignorant to realize that his comments bothered the people. This angered the peasants along with how wealthy he was. But one didnt have to be the Marquis to be punished. Any wealthy man returning to France could be considered an emigrant. For instance, Darnay, a wealthy man, was accused of being an emigrant, so he was immediately sent to prison. As you can see, even the wealthy had no protection under the crumbled government. Lastly, innocent people suffer as the Revolution burned out of control. Innocent people, which included relatives of those directly affected, suffer just because of the overgrown madness. A good example of this would be Lucie and her daughter Little Lucie. Madam Defarge (who was probably the biggest reactionary in the whole book) wanted the whole Manette family to suffer just because Darnay (the nephew of the Marquis) married into the family. Luckily, Little Lucie was not hurt, thanks to Mrs. Pross who put her own life on the line just to save the Manette family. Mrs. Pross, who lived a simple, quiet life, suffered partial deafness from the sound of a single gunshot. Many relatives of the aristocrats received death by the guillotine just because of their family ties and heritage. This was not right, but the people were blinded by their madness to even think about who they were killing and punishing. As illustrated, injustice during the French Revolution affected everyone touched by it because the Revolution claimed so many victims on all sides. Thousands of irreplaceable lives were taken during the time of the Revolution. There were no winners in the outcome of the revolution. These few years were some of the worst France had ever seen. The grindstone had a double handle, and turning at it madly were two men, whose faces, as their long hair flapped back when the whirlings of the grindstone brought their faces up, were more horrible and cruel than the visages of the wildest savages in their most barbarous disguises (Dickens 260). Is it ok to do unjust things in the name of justice? Will there ever be an end to injustice in the world we live in? At the rate were going, we may never reach the desired utopia that we dream of.

Monitor a Safe Workplace Essay Example for Free

Monitor a Safe Workplace Essay |Unit BSBOHS407A |Qualification | |Monitor a Safe Workplace |Certificate IV in Frontline Management | | | |Learner | |Start Date | | |Assessor | |Due Date | | | | |Task |Description |Who |What |Duration | |( 1 |Complete your workbook |Student |Workbook |10 hours | | | | |Text book | | |( 2 |Journal entry (one per week) |Student |Diary |20 mins | |( 3 |Scenario and Questions |Student |Questionnaire |1.5 hours | |( 4 |Underpinning Knowledge Questions |Student |Questionnaire |1.5 hours | |( 5 |Workplace Project |Student |Computer |6 hours (report) | | | | |Work Team |+ time on the job | |( 6 |Supervisor’s Checklist |Supervisor |Checklist |15 mins | | | | |Workplace Project: | | | | | |Create an OHS file for the information you collect while working through this unit. Consider your own organisation, or one that you have researched. | |Include the following: | |description of your organisation; | |organisational chart of your workplace with list of names, positions and responsibilities; | |floor plan of your workplace with emergency exits labeled; | |your organisation’s OHS policy and procedures; | |organisational chart and job descriptions; | |information from relevant state or territory’s OHS authorities; | |information from national OHS authorities; | |Risk Assessment forms and instructions/procedure | |copies of your organisation’s records and reports relating to OHS; and | |information from employees and health and safety representatives. | | | |Categorise the information and write a contents page for the folder/file. | | | |Conduct two (2) Risk Assessments on potential workplace hazards using the organisation’s procedures; attach the documentation. | | | | | |Contact your assessor if you require further information. | | | | | | | |_______________________________________ | |Student Signature | |DECLARATION: The attached information is all my own work | | | Certificate IV in Frontline Management BSBOHS407A: Monitor a Safe Workplace Candidate’s Name: ___________________________________________________ | |C |NYC | |FEEDBACK FROM MANAGER/SUPERVISOR | | | | | | | |Please consider how the candidate GENERALLY performs. | | | |Does your feedback confirm that the candidate can: | | | |Provide information to the workgroup about OHS policies and procedures |( |( | |Implement and monitor participative arrangements for the management of OHS |( |( | |Implement and monitor an organisation’s procedures for providing OHS training |( |( | |Implement and monitor procedures for identifying hazards and assessing risks |( |( | |Implement and monitor the organisation’s procedures for controlling risks |( |( | |Implement and monitor the organisation’s procedures for maintaining OHS for the team |( |( | | | |How does the candidate monitor safety in the workplace? | | | | | | | | | | | |COMMENTS FROM SUPERVISOR REGARDING CANDIDATE’S PERFORMANCE AGAINST THESE COMPETENCIES | | | | | | | |Supervisor’s Name and Signature: | | | |Email: | | | |Qualifications: | | | |Date: | Important: The candidate cannot be deemed competent until this checklist is returned. Please contact the assessor to discuss issues relating to this assessment, Corelink 02 9779 9800. Certificate IV in Frontline Management BSBOHS407A: Monitor a Safe Workplace Candidate’s Name: __________________________________ | | | |ASSESSOR’S OBSERVATIONS |Satisfactory | | | | | |Yes No | |Participates in group activities and group discussion in the learning development environment, OR, responded to |( |( | |assessor’s questions in the required time frame and to the required standard. | | | |Completed workbook activities to appropriate standard |( |( | |Recorded legitimate details of workplace issues in his/her journal and offered these issues and other discussion |( |( | |generating evidence to the workshop group | | | |Discussed and demonstrated an ability to work through issues raised on a one-to-one basis with the assessor (where |( |( | |the assessor coached the candidate through the issue) | | | |Demonstrated underpinning knowledge of the performance criteria for this unit |( |( | |Performance in the learning development environment was at a standard that reflected the candidate’s knowledge and |( |( | |understanding of this unit | | | |Ability to recognise opportunities to transfer learnings from group activities and discussions into the workplace |( |( | |Knowledge of how the elements and performance criteria of this unit integrate with and relate to the candidate’s |( |( | |organisation’s actual strategy | | | |ALL evidence submitted for assessment was appropriate for the level at which the candidate is being assessed |( |( | |Used effective people skills to relate to and communicate with others whilst in the learning development |( |( | |environment | | | | | |COMMENTS FROM ASSESSOR REGARDING CANDIDATE’S PERFORMANCE | | | | | | | | | | | | | |Assessor Name and Signature: Date: | Important: The candidate cannot be deemed competent until this checklist is returned. 1. Notes to Learner: †¢ ALL evidence should be checked off and attached to this document prior to submission for assessment. It is important you supply enough evidence so you can demonstrate that you are capable of performing at the appropriate standard in the workplace. Without the required evidence, you cannot be assessed as COMPETENT IN THE WORKPLACE by your assessor. †¢ The supervisor/third party checklist is to be completed by your supervisor. If you do not have a supervisor (for example, if you are a business owner), contact your assessor to arrange for a suitable third party to complete the checklist. †¢ Whether you are participating in FLM facilitated-learning workshops or learning self-paced, the assessor will complete a checklist to record evidence of your participation in group discussion, group activities or one-on-one interviews and emails. This will record an assessment of your underpinning knowledge and ability to transfer the learnings from the discussion and activities back to the workplace. †¢ Please contact your assessor if you require any assistance whilst preparing or collecting this evidence. †¢ If you do not have the instructions about how to keep a Journal, please contact your assessor. †¢ If you do not understand anything fully, contact your assessor. †¢ Go to Corelink’s website if you need tips on studying via distance learning. QUESTIONNAIRE Certificate IV in Frontline Management BSBOHS407A: Monitor a Safe Workplace SCENARIO Complete your answers using a word processor. The answers do not need to be lengthy (bullet points will do). The company you work for was recently purchased by another, much larger company. Although the employees have been assured that no retrenchments would occur they are still skeptical about what the future holds for them. The new managers appear to be quite open with staff about their vision for the company and have introduced major changes to its work practices to help them achieve their objectives. Workers are required to move to a new safety system. There has never been a formal system in place before. You have been put in charge of the project. Describe how you would go about the following: a. Information Sessions on OHS Legislation b. Method of explaining industry regulations to staff c. Draft of a suitable OHS Policy d. Explanation of how accessible this policy should be to employees e. Procedure for electing OHS representatives and committee f. Explanation of how meetings will be conducted g. Consultation methods you will use, and as assessment of that consultation with employees regarding the identification of workplace hazards h. Training requirements i. A checklist relating to hazards in your work area j. Draft of an Incident Reporting Procedure UNDERPINNING KNOWLEDGE QUESTIONNAIRE Certificate IV in Frontline Management BSBOHS407A: Monitor a Safe Workplace Complete your answers using a word processor. The answers do not need to be lengthy (bullet points will do). 1. Discuss the responsibilities that OHS legislation places on employees and managers 2. Describe the legal responsibilities of safety representatives and committees 3. What is meant by an employer’s OHS ‘Duty of Care’? 4. What should OHS audits evaluate? 5. What OHS records should be maintained? 6. Why do we have OHS policies and procedures? 7. Corelink PTY LTDAssessment Tool  ©Corelink Pty LtdAssessment Tool

Factors that lead to employee motivation

Factors that lead to employee motivation Employees are considered as one of the most valuable asset of an organization and they contribute to various activities of an organization. There is a need in every organizational to motivate their employees in order to render organizational commitment of the employees and if an employee is committed toward to an organization than there will be strong desire in an employee to work toward s the goals of an organization and to remain in the organization which will in turn lead to success of the organization. The purpose of this research is to examine and evaluate the factors which motivate the employees. One reason for choosing this topic is that it is an important fact that employees spend a lot of time at work for almost 40 years of their lives therefore it is important that employees should be satisfied with their job and the working environment. Apart from this topic being so interesting and important, there are different theories than can be used to look at motivation from different angles. Reasons for choosing Pepsi Pepsi co has a work oriented approach with highly skilled and knowledgeable employees. Pepsi is a world leader in producing beverages and other consumer product. PepsiCo in Pakistan produces financial rewards for its investors and provide growth opportunities to its employees. The aim of the management of PepsiCo is to build a work force that is motivated and associated with the objectives of the organization. At PepsiCo both financial and non financial practices are undertaken to motivate the employees. My research will focus on the non financial practices for motivation. Project Objectives and research questions: The objective of this research is to understand the factors that motivate employees. Employees not only focus on financial rewards but also non financial rewards and benefits which are responsible for motivation among employees. The objective of this report focuses on the impacts of non financial practices on employee motivation. A smaller part of this report will focus on the financial factors responsible for motivating employees. The main aim of this research is to identify and analyze the factors that motivate the employess using different theories of motivation. Both primary and secondary sources will be used to identify these factors. Primary research will give more detailed and in depth analysis. The main primary question will be: Are PepsiCo employees motivated? What factors lead to employee motivation? How can PepsiCo improve motivation of its employees? The answers to the above three questions will help in identifying and analyzing the areas of strengths and weakness in overall motivation process at PepsiCo. At the end recommendation will be given that how Pepsi can improve and work on their areas of weakness. Overall research approach: To begin with the research first of all I will analyze whether the employees at PepsiCo are motivated or not. I will use results obtained from primary research and secondary sources to do the overall analysis of motivation. Once I have found that employees at PepsiCo are motivated or not I will identify and analyze the factors that are responsible for motivating employees or responsible for their dissatisfaction. The factors that I will use will be based on the theories of motivation I will be using. There is at least one question in the primary research questionnaire for each factor. The questionnaire will ask the participating employees to put in order of importance the factors they consider are most important and will motivate them. The theories that I will be using are: Herzbergs motivation hygiene theory Vrooms expectancy theory From the information that I will obtain from primary and secondary research I will make recommendations to PepsiCo that on which factors they can improve on and which factors they should not focus on as they do not help in motivating employees. Finally in the conclusion I will discuss the overall effectiveness of the motivation process of employees at PepsiCo. Part 2: Sources and methods used for collecting information: The secondary sources that I am using for my research are websites, books and business magazines, whereas primary research will be conducted through a questionnaire. The questionnaire was distributed among different employees working at different positions at PepsiCo. The questionnaire has at least one question relating to the factor considered. The participating employees were asked to put in order of importance the factors that the considered are the most important for their motivation. This help me identifying that where PepsiCo is putting its emphasis and on what factors it is not putting much emphasis. Limitations of your information gathering Ethical issues and how they were resolved The main ethical issue concerned was of confidentiality as this report discusses private personal information as well as information about PepsiCo which gives PepsiCo completive advantage. To overcome the issue of confidentiality the surveys are kept anonymous and individual results will not be shown. I am a customer of PepsiCo and I am an admirer of it. However I ensure that my results are not biased in favor of PepsiCo. I made sure that I focused on the factual data for my results. Accounting and/or business techniques and their limitations Motivation is the psychological feature that arouses an organism to action toward a desired goal; the reason for the action; that which gives purpose and direction to behaviour (Princeton, 2010). There are two types of motivation theories, process theories and content theories. According to content theory man has needs which tend to change over time. Man will be motivated when these needs are satisfied. Therefore the theory identifies factors that are needed to be satisfied in order to motivate an individual. Whereas process theories believe that motivation leads to actions which will satisfy an individuals need. Content theory believes thats if needs of an individual are satisfied then he is motivated whereas process theories believe motivation leads to actions that can satisfy needs. There are two types of process theories, expectancy theory and equity theory. According to expectancy theory an individual has to expect that their ability and skill will help them to complete a task which will lead to fulfillment of desired need. Therefore a job design is important. Equity theory analyzes the ratio between an individual input and the expected outcome. An individual input includes his effort, his ability, his training etc where as the expected outcome includes the pay he is getting, his status etc. An individual is de-motivated when he believes that his input to output ratio is not similar to his coworkers in the company. For example if one employees earns à ¢Ã¢â‚¬Å¡Ã‚ ¬200,000 of revenue for the company in a year and earns an income of à ¢Ã¢â‚¬Å¡Ã‚ ¬30,000 whereas his coworker who has been at the company for 4 years longer than him earns an income of à ¢Ã¢â‚¬Å¡Ã‚ ¬40,000 even though he also earns à ¢Ã¢â‚¬Å¡Ã‚ ¬200,000 of revenue for the company. For my research project the motivation theories I have chosen is one process and one content theory, which are discussed below: Herzbergs Hygiene Motivation theory Frederick Herzberg (1966) was a student of accountants and engineers in Pennsylvania and he identified the two-factor theorem for job satisfaction. He noted that the opposite of satisfaction is not, no satisfaction but is dissatisfaction. Therefore the two factors he indentified ere hygiene factors and motivating factors. The hygiene factors are those which remove job dissatisfaction and motivating factors are those which cause job satisfaction. Hygiene factors are the needs which an employer must provide in order to stop an employees dissatisfaction. Some of the primary hygiene factors are : Company policy Supervision Working conditions Relationship with peers Salary Security These factors are all external and will satisfy human physiological needs. Physiological needs include such as food and shelter etc Whereas motivating factors will satisfy a persons psychological needs and are fundamental. The important motivating factors are: Achievement Recognition Work itself Responsibility Advancement and Growth Motivating factors will not be met until and unless hygiene factors are not met. However if both factors are successful then the employees will be loyal and will be more productive. Now looking at the limitations of the theory: The first limitation this theory has is that it does not see employees as individuals with different personalities. As all human beings have different needs and different wants therefore it is inappropriate to consider that same factors will motivate everybody. The second limitation with this theory is that it assumes that only motivated employees are productive however this may not hold true in some cases. Therefore it can be seen that theory does not consider an individuals ability and his skills. Also at time the managers blame that hygiene factors lead to employees dissatisfaction and they tend to ignore the motivating factors, which may be the main reason for an employees de-motivation. Vrooms Expectancy theory of motivation. Vroom presented the following equation for motivation: Motivation = Valence x Expectancy (Instrumentality) In this equation Valence means the depth of want and expectancy and instrumentality considered the employees perception about his chances of receiving bonus or reward. This theory is based on the employees ability to predict whether he will be able to complete the given task. This ability to predict can be low for tasks which are complex and in such cases the theory will be considered ineffective. Part 3 Results, analysis conclusions and recommendations Are employees at PepsiCo motivated? Interest in task According to the content theories, when an individual is attracted in what they are doing it motivates them to complete the task. According to Herzberg this is an essential factor and therefore is a need to develop this factor in the employees. Therefore it is important to understand that if the need for interest of the employees is satisfied than they will be motivated to work and perform the task successfully. Process theorists also agree that interest fac t is important for motivation bur however according to them, individuals are motivated because they believe that they will get the desired reward. According to Vroom if an individual is interested in their wok and are satisfied with their job then they will believe that they will succeed and they are motivated to work for their success. Hence Interest in task by the employee is an important factor and PepsiCo should give time to it. Graph exp As in the questionnaire question 1 and 2 are about the factor interest in task. The results shows that employees at PepsiCo believe that their work task gives them personal satisfaction as they have answered these questions as agree and strongly agree. None of the employees said that they were dissatisfied with their job, however it is seen from the survey that satisfaction level of some employees need to be improved therefore there is a room for improvement for PepsiCo. Also on the important list of the survey this factor varies from levels 1 to 9, which shows that how different employees view this factors importance. This shows that the result match with Vrooms theory because the employees feel that interest in task does not have a positive relation with skills and ability and the results does not correlate with Herbergs theory which believes that interest in task is a motivator. Recognition Recognition means that you are acknowledged by the other because of your good performance in a task. According to Herzberg recognition is an important intrinsic motivating factor because it gives an employee the feeling of self worth and an employee feels good about himself. If an employee feels good about him and is confident then he will be motivated as well. According to Vroom recognition makes an employee motivated to do the work again as he knows that it will lead to success. Process Theorist believe on larger rewards such as financial bonuses where as Herzbergs theory prefers smaller rewards and frequents recognitions for making one feel good about himself. Graph Working environment According to Herzberg working environment is a hygiene factor that is required to keep away dissatisfaction but it is not a motivator itself. According to Process theories a factor is only motivating if it helps individuals in achieving a specific goal. According to Vroom a working environment is a motivator as it is required to perform a task. This factors shows that how both theories have different conclusions about it. Graph n explanation 4. Relationship with peers According to Herzberg relationships are not needed by individuals as they are an external factor. Content theories don not encourage companies to spend their resources on building relationships among peers. According to Vroom the need for relationship among peers is important depends on whether it is an important factor in achieving success. According to the equity theory motivation depends how individuals sees themselves by comparing himself with the others in the same organization. Graph n explanation Relationship with senior The use of the theories for this factor is alike to the conclusion drawn in the above factor relationships with peers but process theorist would see this factor as a motivating factor because it is important to build relationship with seniors and gain their respect in order to get promotion. Graph n explanation Reasonable expectations from the organization Reasonable expectations mean that a just quantity of work is given by the manager. According to Herzberg this factor is a hygiene factor and not a motivator because unreasonable expectations from the manager will lead to dissatisfaction even if other motivating factors are also present. According to Vroom this is a motivating factor because if they expectations are reasonable the employee will believe that he will be able to succeed and hence will be motivated to perform the task. Graph n explanation Career advancement According to Herzberg career advancement is a motivating factor because it indicates personal growth and the employee who is given growth opportunities and promotions will be motivated to work. According to process theorists career advancement is a motivating factor as long as the individual feels that it is realistic and the expectations for promotion are high. According to Vroom career advancement is a motivating factor as this will lead to employees ability to succeed. Graph n explanation Company Pride Graph n explanation 9. Monetary rewards Graph n explanation 10. Job Security Graph n explanation Sample questionnaire Gender: Male Female Age Length of time working at the company: Less than 1 year 1-3 years 4-6 years 7-10 years More than10 years Department: The numbers indicate the following: 1 Strongly disagree 2 -disagree 3 Neutral 4 -agree 5 Strongly agree My work is interesting. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree Doing my job fine gives me personal satisfaction. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree My manager gives me recognition when I do an excellent job. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree The company has reasonable expectations from its employees. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I am satisfied with the working environment 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree There is a feeling of teamwork in the company. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree The people I work with improve my job satisfaction 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I respect my manager as a capable professional. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree My manager treats me with respect. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I have satisfactory opportunities for professional growth in this company. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I am satisfied with the level of training 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I am rewarded for the work I perform 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I would leave the company if I was offered better salary at another company 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I feel my job is secure 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I expect to leave the company within the next 12 months 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree I am proud to work for the company. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree Overall, I am very satisfied with my job at the company. 1 2 3 4 5 . Strongly disagree disagree neutral agree strongly agree Put the following in order of importance to you regarding your satisfaction (number 1 most important, 9 Least important, next to each item) Interest in job Recognition Working conditions Relationship with peers Relationship with seniors Reasonable expectations from my manager Career progression Monetary rewards Job Security Other Please state

Jeffrey Dahmer :: Biography Biographies Bio

Jeffrey Lionel Dahmer came into the world at 4.34pm on the 21st of May at the Evangelical Deaconess Hospital in Milwaukee 1960. Little did his parents know at the time of his birth that there son would become one of America's most infamous serial killers, not only for the amount of victims which he had killed, but also for dismembering them and his odd tendencies. Jeffrey's childhood started like any other, he had two parents who loved and adored there son dearly. They would give him what ever his heart desired. Joyce Dahmer started a scrap book on her son recording events that happened in his life, his first step, his first accident, his first tooth, his first haircut and even his first scolding. While Jeffrey was still very young his father worked long hours in his laboratory and his mother worked as a machine instructor. But the carrying of Jeffrey had been hard on Joyce Dahmer and every little thing seemed to annoy her. So Lionel being the husband that he was and wanting the best for his wife decided to move to his mothers house in West Allis, but the crack's in the marriage started to show early. There were constant fights between Joyce and Lionel Dahmer and Jeffrey took each of these fights to heart. Little did they realize that there constant fighting would be one of the reasons for Jeffrey's downfall and eventual collapse into deviant crimes. A short time before Jeffrey's fourth birthday, Jeffrey was diagnosed with a double hernia that needed to be operated on. This operation left Jeffrey feeling open and exposed nobody explained to him what was going on. He felt scared by the operation, complete strangers coming up to him and exploring his body. This experience is said to have marked his subconscious forever. But like every little boy of Jeffrey's age he was just like anybody else climbing apple trees, riding his bike and playing in coal dust and coming home dirty. Although he was painfully shy while growing up he over came this in time, and had a normal social life at school. By the time Jeffrey turned six his mother gave birth to a second son who she called David. Though this did not have a dramatic effect on Dahmer's life he stayed pretty much neutral to his brother’s existence and they never became close. By the time of his second son's birth Lionel Dahmer and his family moved into there own house at 4480 West Bath Road, surrounded by open forest where Jeffrey could lose himself in a world of make believe.

The Supernatural in Shakespeares Works Essays -- William Shakespeare

The Supernatural in Shakespeare's Works No one questions the fact that William Shakespeare is a pure genius when it comes to creating immortal characters whose characteristics transcends those of the normal supernatural beings, but most students of literature agree that his uses of the supernatural aren’t merely figments of his creative imagination. Every man, woman, and child is influenced by the age into which they are born and Shakespeare was no exception. Not only does his use of supernatural elements within his works reveal the Elizabethans’ obsession with mythical beliefs, but it also reveals his attitude toward these beliefs at different points of his writing career. Because of the profound understanding of the beliefs of his time, Shakespeare was able to create masterpieces that critics and readers have respected all over the world. In Shakespeare’s time, the belief in the presence and power of the supernatural touch life at every point. Customs were formed by it and behavior was dictated by it. Not only did the poor believe in it, but all classes of people were under its spell from nobles to the poor. It governed people’s lives down to the smallest details. They carried charms and mascots, found horror in spilling salt and walking under ladders, and dreaded the thirteenth of Friday (May 35-38). They believed that all supernatural elements were at work. The Elizabethans had always been susceptible to belief in the supernatural. As May notes, these people more that other people questioned matters beyond their vision (39). Shakespeare was clearly influenced by his race. He had an inquiring mind that refused bondage by the limitations of matter (Mish 28). Listing the numberless superstitions that Shakespeare gathered from his environment would be impossible. May believes that it is because his own observations of the habits of animals and plants were explained by stories that were more myth that truth. Elizabethans also gave superstitious explanations for changing weather and season, phase of life, and sickness and death (59-63). As a youth, Shakespeare was susceptible to all kinds of influences around him. Due to the widespread obsession with the supernatural, Shakespeare was compelled as a writer to adopt the views of the majority. The people who crowed the theaters and paid the money demanded fairies, ghost, and witches, and all the commonly h... ...onio for the terrible wrong he has don and no traces of anger or resentment linger. In this final play the supernatural is entirely beneath the control of man. All authority is taken form the spirits in The Tempest and the power to harm is gone. Shakespeare’s state of mind is best expressed at this point when Prospero reveals how man has at last attained dominion over the forces of evil (Schiller 378). William Shakespeare was a genius. Not only was he able to use the supernatural in his works to the fullest extent of Elizabethan belief, but he was skillful at molding the supernatural into remarkable assets to his plot. However, Elizabethan beliefs weren’t the only influences that shoved their way into the meanings of his plays. His whole outlook on life also played a major part in the way that he shaped the supernatural. Not only does his use of supernatural elements within his works reveal the Elizabethans’ obsession with mythical beliefs, but it also reveals his attitude toward these beliefs at different points of his career. His remarkable handling of the supernatural is on reason why William Shakespeare is generally regarded as the greatest writer of English literature.

Sexually Explicit Advertising is Detrimental to Society Essay -- Argum

Sexually Explicit Advertising is Detrimental to Society Just how far should advertisers go to sell a product? Individuals are reminded that a new age in advertising has emerged when Britney Spears and Victoria's Secret model Tricia Helfer grace the cover of Forbes, a traditionally mature financial magazine. However, as any good advertiser knows, sex sells; all people need to do is look at a newsstand or magazine rack. But while it sells, it also offends as the promiscuous use of sexual images in advertising rubs many consumers the wrong way. The current increase of sexually explicit advertising, while increasing sales, has many detrimental effects on society. New regulations or other forms of control need to be implemented to protect children and others who are defenseless against the war to win consumers. According to a nationwide poll conducted for Adweek by Alden & Associates of Hermosa Beach, CA, people were asked whether they thought there is too much sexual imagery in advertising. A landslide of 73% said there is, with respondents in the 35-49 ag e bracket more likely to say so as concerned parents (Dolliver, 1). There is a struggle among advertisers on whether to use the sure way to sell the product (through sexual images) or to be true to a sense of morality. More often than not, greed takes o ver and morality is thrown out the window. The problem is that sexual appeal used as a marketing tool seems to be showing up more often with a broader range of products and audiences. All too often sexually explicit ads appear in magazines such as YM, Teen, Self, Glamour, Seventeen, and Cosmopolitan, all of which have a target audience of 11-17 year olds who have not yet developed adequate defenses against sexually expli... ...p 19 March 2001. â€Å"The Joy of Sex.† Adweek 6 March 2000: 22. Online. EBSCOhost: Academic Search FullTEXT Elite. (AN: 2896174) 19 March 2001. Marks, Alexandra. â€Å"A Backlash to Advertising in Age of Anything Goes.† Christian Science Monitor 22 Feb. 1999: 91. Online. EBSCOhost: Academic Search FullTEXT Elite. (AN: 1562687) 19 March 2001. Menzies, David. â€Å"Sex Education 2000.† Profitguide.com Oct 1999. Online. http://profitguide.com/sales/C6-art.asp?ID=143 19 March 2001. Miller, Michael. â€Å"Sex Sells, But It's Rarely Clever Now.† Capital District Business Review 12 June 2000: 27. Online. EBSCOhost: Academic Search FullTEXT Elite. (AN: 3383375). 19 March 2001. National Institute of Child Health and Human Development. â€Å"The Impact of Media on Adolescents' Sexual Behavior.† 10 June 1998. Online. http://grants.nih.gov/grants/guide/pa-files/PA-98-079.html 19 March 2001.

The Evolution and Mechanism of Immunological Memory and Its Impact on Immunology Research.

The Evolution and Mechanism of Immunological Memory and its Impact on Immunology Research. Recently, the Center for Disease and Control reported that it has discovered a super bug, a bacteria, that has the capability of resisting almost any antibiotic known to human. In addition to resisting antibiotics, these superbugs are deadly. Not only do the bugs cause death to half of the patients with serious infectious diseases, but they also spread their genes that make the bugs resistant to other bacteria cells (USA TODAY, 2013). This class of superbugs is known as carbapenem-resistant enterobacteriaceae (CRE).Currently, CRE are found mainly in hospitals and nursing homes. However, if these bacteria escape into the environment, the results can be devastating. For instance, the bacteria may cause small diseases, such as the common cold, to become untreatable because the CRE alters the small disease genetics in a way where it is resistant to vaccination and other medicines (USA TODAY, 2013). Although this type of bacteria is new and deadly, it is not the first time that the world has encountered something similar to CRE. For instance, Staphylococcus aureus is one of the well-known examples of bacteria that are resistant to antibiotics.One reason doctors use antibiotics is because bacteria are often resistant to the immune system of a body. The resistance of bacteria to the immune system is due to natural selection and genetic mutation. Because bacteria reproduce at a rapid rate, some bacteria that contain the adaptive, resistant traits survive and reproduce offspring that contains the resistant genes. They produce immune-resistant genes through genetic mutation. The alteration made by the genetic mutation can create a trait that is resistant to the immune system.As a result, the genetically mutated bacteria will be able to reproduce without interference from the host’s defense system. As a powerful tool that the body uses to protect itself from pathogens and bac teria, the immune system consist of several parts, and the immunological memory is one of the most important. Understanding the evolution and the mechanism of both the immune system and immunological memory, new research areas can be developed and new vaccines can be created that target the immune systems of pathogens or that alter the immune system to make it more efficient in combating pathogens.Evolution of the innate immune system and the innate memory Organisms of the same species’ innate memory are almost the same. This memory comes from millions of years of evolution (Sompayrac, 2008). The immunological innate memory is based on pattern recognition receptors. Pattern recognition receptors are the main components that allow the innate immune system to recognize the pathogens and activate antigens (Kurtz, 2004). These receptors have gone through millions of years of evolution. One of the main receptors is the Toll-like receptors (TLRs) (Sompayrac, 2008).Instead of studyi ng the body’s defense to pathogens, current research investigate the evolution of the innate immune system through observing the examples of specific receptors in simple organisms. Wu and Huan (2011) are studying the Toll/interleukin-1 receptor (TIR) and the leucine-rich repeat (LRR), which are the two domains that make up the TLR. TIR and LRR are connected by a transmembrane helical starch that is 20 amino acids long. TIR plays an important role in activating the innate immune system by detecting lipopolysaccharide from gram-negative bacteria.The interaction between the receptors of both the innate immune system and bacteria is handled by LRR. Figure 1: Illustration of evolutionary tree of invertebrates. Amphimedon came before Cnidarians. (Wu and Huan 2011) To understand the evolution of TLR, scientists have to discover when the TIR and LRP first appeared. One research conducted by Dr. Wu and coworkers (2011) attempted to create a phylogenetic tree of the TLR. After comparin g the protein of different organisms, they discovered that sponges, such as Amphimedon queenslandica, contained a single TIR domain that was distinctly related to the TLR of vertebrates (Wu and Huan, 2011).The finding prompted them to conduct further analyses of TIR proteins in organisms that appeared later than Amphimedon queenslandica. As shown in Figure 1, cnidarians appeared after Amphimedon queenslandic. Cnidarians had TIR proteins that were similar to that of vertebrates. Cnidarians are one of the simplest organisms, and their TIR proteins allow them to have the characteristics of allorecongnition, the ability to distinguish its own tissue from another (Wu and Huan, 2011). LRR was not found in cnidarians.The finding of TIRs that were similar to vertebrates in cnidarians only answered part of the question. Wu and Huan were not able to find the first appearance of LRR. They found the combination of LRR and TIR to make TLR after analyzing the TLR proteins of three basal deuterost ome invertebrates and five protostome mammals. The conclusion is that the combination of TIR and LRR occurred after the divergence of bilateria and nonbilateria. After the separation, the receptors became more complex because they started to have the capability of allorecongnition and a killing mechanism (Wu and Huan, 2011).After further comparison of the TLR of vertebrates, they determined that another combination occurred between the TIR and LRR during the evolution of primates (Wu and Huan, 2011). They believe that this second combination gave rise to our present TLR, which has the capability of signaling the innate and alerting the adaptive immune system. The innate immune system is the oldest defense system. Because of this, the earliest form of the innate immune system of simple organisms, such as cnidarians, are closely related to vertebrates, such as people.As organisms moved from water to land, they encountered more types of pathogens. Pressure from pathogens caused many or ganisms to develop an innate memory that is more expansive. However, as organisms became more complex, the innate memory did not adequately protect the organism. The inadequacy of the innate immune system leads to the formation of the adaptive immune system. Evolution of the adaptive immune system and the adaptive memory The adaptive memory is different from the innate memory because the receptors in the adaptive memory begin life with a blank memory.There are two major types of lymphocyte receptors that play an important role in the adaptive memory: B cell and T cell. It is hypothesized that B cell receptors (BCRs) and T cell receptors (TCRs) have a common ancestor (Flanjnik et al. 2010). The characteristics of these genes are discovered in gnathostomes, but not in agnatha. These characteristics include being able to have large amount of cells for differentiation. This finding caused scientists to create a theory called the ‘big bang theory’ of adaptive immune system ( AIS) emergence.The finding also prompted scientists to examine the changes of these receptors’ characteristics from gnathostomes to mammals. These finding lead scientists to determine the origin and evolution of the adaptive immune system. Figure 2: A summary of the immunoglobulin’s structures and functions found in gnathostomes to mammals. The first receptor that researchers focused on was the B cell receptors. Immunoglobulin M (IgM) is a B cell receptor that has the same function in all organisms starting from the gnathostomes (Flajnik and Hasahara, 2009). Some of these functions include having its transmembrane form defining the B cells.In humans, IgM is responsible for increasing the complement activation during the interaction of antigens and lymphocytes. This characteristic caused the IgM to be very efficient at causing lysis in microorganisms. IgM also causes clumping of pathogens. The clumping of pathogens was discovered in bony fish, while the increasing of th e complement activation was found in cartilaginous fish. This showed that although the function of IgM did not change, it was altered as organisms became more complex. Immunoglobulin D (IgD) is another B cell receptor.IgD is different from IgM because although both humans and bony fish have IgD, IgD in humans is attached to the surface of basophils, while in bony fish, the IgD is attached to granulocytes’ surface (Flajnik and Hasahara, 2009). Although the function of IgD is still unknown, the finding of IgD at two different locations indicates that there are possible changes in its functionality. The only vertebrates that do not have IgD are birds. These findings support the idea that like IgM, IgD is an old antibody class that has changed its function from gnathostomes to mammals. Amphibians have a B cell receptor known as IgY.Mammals have IgG, IgE, and IgA B cell receptors. Mammals obtained IgG and IgE through the alternative splicing of IgY. IgG has the same function as Ig Y. IgE’s function is different from IgG because it is responsible for releasing various pharmacological mediators, while IgG’s function is to activate complement when reacting with an antigen. IgA is found in reptiles. The discovery of IgE, IgG, and IgA in mammals reinforces the idea that as organisms became more complex the type of immunoglobulin receptors increased, thus making the adaptive immune system more complex. Like BCRs, some TCRs had a similar situation. ? T cell receptors from jawed fish to mammals have the same function. ? T cell receptors in both sharks and marsupials are structurally the same. Both sharks and marsupials have three domain receptor chain with two amino-terminal V domains and a membrane-proximal C domain. However, the formation of the V domains and C domains are different for sharks and marsupials. The V domain for sharks is made from VDJ rearrangement, while the V domain for marsupials is generated by one set of V, D and J segments of a pr e-rearranged VDJ gene. The function of these receptors has not been reported.The difference in the formation of the V domain indicates that due to pressure from the environment, part of the adaptive immune system underwent evolution to meet the needs of marsupials. Examining the change of the receptors from the gnathostomes to mammals has shown that the adaptive immune system underwent change as organisms became more complex. However, this does not illustrate how the adaptive immune system formed. The recombination-activating gene (RAG) transposon and the whole-genome duplication are the two events that brought about the adaptive immune system (Flajnik and Hasahara, 2009).RAG encodes enzymes that impact the rearrangement of T cell receptors and immunoglobulin. There are two main types of RAG in vertebrate immune system: RAG-1 and RAG-2. These two types of RAGs play a major role in the formation of immunoglobulin superfamily (IgSF). During the 1970s, two Japanese researchers discover ed that recombination signal sequences (RSSs) were flanked by V,D, and J rearranging segments. These segments within the RSSs had repeats that were reminiscent of a transposon. From this, they reasoned that a transposon invaded IgSF (Flajnik and Hasahara, 2009).The invasion resulted in IgSF not being able to function unless through recombinase. Flajnik and Hasahara believed that IgSF genes were invaded by the RAG transposons. Researchers could not obtain all RAG genes from agnatha, but they were able to obtain it from gnathostomes. This indicates that the RAG transposon plays a role in triggering IgSF (Flajnik and Hasahara, 2009). The invasion of the genome by the transposon was vital for the adaptive immunity system because it gave rise to BCR and TCR, which are part of the IgSF and both play a major role in the adaptive immune system.The occurrence of whole genome duplication also plays a role in the formation of the vertebrate adaptive immune system. Susumu Ohrno was the first re searcher to propose the idea that the vertebrate genome underwent two rounds of whole gene duplication (WGD), which occurred after the emergence of the jawed vertebrates. WGD is an event that creates an organism with additional copies of the entire genome. At first, this idea was met with great skepticism but scientists now accept the idea because many ohnologues are essential components of the jawed ertebrate adaptive immune system. Ohnologues are paralogues that are close to the origin of vertebrates through whole-genome duplication (Flajnik and Hasahara, 2009). Understanding what influences the evolution of the adaptive memory is also important in understanding the evolution of the adaptive memory. There are many speculations on why the adaptive immune system is developed. Some reasoned that because the innate immune system was inefficient and difficult to regulate, it lead to the development of the adaptive immune system.Pressure from pathogens and the ability to have few offspr ing also caused natural selection to favor the formation of an adaptive immune system (Flajnik and Hasahara, 2009). For instance, organisms such as seahorses live in an environment that has few pathogens that will threaten its livelihood. In addition, seahorses produce large amount of offspring. Because there are not many pathogens that a seahorse encounters, the innate immune system is adequate in dealing with the few pathogens. Organisms such as sharks are predators, and many produce few offspring during their lifetime.This pressurizes sharks to have an adaptive immune system because the offspring will have the ability to combat pathogens of all types. Sharks adaptive immune system is not as complex as vertebrates that dwell on land because water does not contain as many pathogens as compared to land. Mazmamian of California Institute of Technology recently conducted a research that indicated that microbiota had a larger influence on the evolution of the adaptive immune system tha n pathogens’ influence (Lee et al. , 2012). Microbiota have a symbiotic relationship with the body.An example of this occurs with bacteria located in the gut. A function of these bacteria is that they help food move quickly through the body. Researchers have discovered that the microbiota, which includes bacteria and viruses, have many different antigens. This provides the adaptive immune system and the microbiota with a challenge because the immune system must either react toward or ignore the foreign antigen (Lee et al. , 2012). In order to prevent overreaction from both parties, both the adaptive immune system and the microbiota develop tolerance through the expansion of regulatory T cell (Lee et al. , 2012).Scientists speculated that this symbiotic relationship between vertebrates and microbiota could have influenced the adaptive memory because symbiotic microbiota could have pressured vertebrates to develop the current adaptive immune system that have developed tolerance to bacteria that is good for the body (Lee et al. , 2012). Current research applications Edward Jenner was the first to start experimenting with vaccines. Afterwards, research on vaccines became more complex. Vaccine researches now include the study of the pathogens and virus’ immune system. Mycobacterium tuberculosis and human immunodeficiency virus.One of the most studied pathogens is the Mycobacterium tuberculosis. Currently, there are two standard strategies to combat Mycobacterium tuberculosis. The first strategy involves identifying the protein that is produced by the bacterium that is essential to its virulence (Flynn, 2004). Once the protein is identified, the immune system can neutralize the protein. This will result in the bacteria not being infectious to the body. This strategy cannot be applied to Mycobacterium tuberculosis because although there is ongoing research, scientists have not been able to identify the protein that causes its virulence (Flynn, 2004).Myc obacterium tuberculosis’ main virulence is its ability to survive within macrophages. The second strategy is to use an attenuated form of the pathogen, which will cause an effective immune response, but will not cause disease. The second strategy involves the adaptive memory immune system because the vaccine is causing the adaptive memory to remember the pathogens that is similar to Mycobacterium tuberculosis. Currently, the second strategy is implemented through the vaccine Bacillus Calmette-Guerin (BCG) (Flynn, 2004). BCG is used by 4 million people around the world (Flynn, 2004).Although BCG is the most commonly used vaccine to treat tuberculosis, it is still not effective because the vaccine can only prevent tuberculosis only in children, but not in adults. Researchers are now investigating the immune response to M. tuberculosis in order to create more effective vaccines. Current research involves injecting patients with the cytokine interleukin 12 (IL-12) (Flynn, 2004). Il-12 plays an important role in controlling M. tuberculosis infection. Studies have shown that when mice are injected with the Il-12 DNA, the amount of bacterial numbers of M. tuberculosis is greatly reduced.Tumor necrosis factors ? (TNF-? ) and interferon-gamma (IFN-? ) are important cytokines that play an important role in combating M. tuberculosis. IFN-? is a central cytokine in control of M. tuberculosis because it activates the macrophages to attack M. tuberculosis (Flynn, 2004). Organisms with defective IFN-? are more susceptible to infections. TNF-? is important because in synergy with INF-? , it leads to the formation of nitrogen oxide synthase 2 (NOS2) (Flynn, 2004). Although NOS2’s role is not clearly known, it is shown that when organisms were under the infection of M. uberculosis, NOS2 expression was low (Flynn, 2004). This indicates that a high expression of TNF-? , IFN-? , and NOS2 can cause the body to fend off tuberculosis. It is known that overexpression of TNF-? can also cause harm to the body by increasing the chance of getting tuberculosis (Flynn, 2004). As a result, researchers are now conducting vaccine research on how to create the right amount of expression of the three cytokines that allow the immune system to effectively combat M. tuberculosis. The human immunodeficiency virus (HIV) is another area targeted for vaccine research.Currently, there are three vaccines approaches in creating a vaccine that targets the HIV-1 protease (McMichael et al. , 2009). HIV protease is an important aspect of the HIV life cycle. All of these methods have failed. Scientists are now proposing to use less empirical approach and to focus more on understanding the immune response to HIV-1 infections when producing new vaccines (McMichael et al. , 2009). During an HIV infection, natural killer cells (NK) become activated. NK cells have the ability to control HIV replication through cytolysis of the infected cells.NK cells also have the capacity to in fluence T cell responses (McMichael et al. , 2009). HIV-1 has responded by reducing its receptors, making it harder for the NK cells to detect the infected cells. Current research is focused on priming the antiviral activity of the NK cells through vaccination. Researchers are cautious when activating the innate immune system because the innate immune response can be harmful because the activation of the innate immune system produces pro-inflammatory cytokines and chemokines, which can promote the HIV-1 replication (McMichael et al. , 2009).As a result, the vaccine-induced activation of the innate immune system must be thoroughly tested and used with caution. Conclusion There are many laboratories around the world conducting research on creating an effective vaccine to target the different diseases that people combat every day. Although this strategy is new, implementing a research strategy that focuses more on the immune system when creating vaccines will allow the vaccine to be mo re effective. In addition, implementing this strategy requires deep understanding of the mechanism and evolution of both the innate and adaptive immune systems.Both the innate and adaptive immune system evolve from being able to perform simple tasks in primitive organisms to perform complex tasks in complex organisms, such as humans. Therefore, in order to create a vaccine, it is vital to start from simple organisms. Once that is accomplished, one can build on top of the newly developed vaccine that targets more complex organisms and combat the superbug carbapenem-resistant enterobacteriaceae. Literature Cited 1. Flajnik and Hasahara, Martin F. , and Masanori Kasahara. â€Å"Origin and Evolution of the Adaptive Immune System: Genetic Events and Selective Pressures. Nature Reviews Genetics 11. 1 (2009): 47-59. Print. 2. Flynn, JoAnne L. â€Å"Immunology of Tuberculosis and Implications in Vaccine Development. † Tuberculosis 84. 1-2 (2004): 93-101. Print 3. Kurtz, Joachim. â⠂¬Å"Memory in the Innate and Adaptive Immune Systems. † Microbes and Infection 6. 15 (2004): 1410-417. Print 4. Lee, Yun Kyung, and Sarkis K. Mazmanian. â€Å"Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? † Science 330 (2012): 1768-773. Print. Kurtz, Joachim. 5. McMichael, Andrew J. , Persephone Borrow, Georgia D.Tomaras, Nilu Goonetilleke, and Barton F. Haynes. â€Å"The Immune Response during Acute HIV-1 Infection: Clues for Vaccine Development. † Nature Reviews Immunology 10. 1 (2009): 11-23. Print. 6. Sompayrac, Lauren. How the Immune System Works. Malden, MA: Blackwell Pub. , 2008. Print 7. USA TODAY. â€Å"CDC Sounds Alarm on Deadly, Untreatable Superbugs. † USA TODAY. N. p. , 5 Mar. 2013. Web. 23 Mar. 2013. 8. 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